Dean Madden

Vice Provost for Research
Dartmouth College

Dean Madden is a Professor of Biochemistry and Cell Biology in the Geisel School of Medicine at Dartmouth. He also serves as PI and Director of the COBRE Institute for Biomolecular Targeting and the Dartmouth Cystic Fibrosis (CF) Research Center. His research interests include ion-channel conformational flexibility, trafficking, and localization. In the context of CF, Dean’s lab focuses on the molecular interactions that regulate the half-life and overall abundance of functional CFTR. The group then uses biochemical and structural approaches to develop patented and patent-pending inhibitors of endogenous and bacterial protein targets. Dean received his A.B. in Physics (1985) and his Ph.D. in Biophysics (1992) from Harvard. During a post-doctoral fellowship, and then as an independent group leader at the Max Planck Institute for Medical Research in Heidelberg, Germany, he directed his interests towards ion channels and their molecular structures and interactions. He joined the Dartmouth faculty in 2002.